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Human ACE2 Protein (FLAG Tag)

Human ACE2 Protein (FLAG Tag)

Catalog Number:
P001417436ABE
Mfr. No.:
Abe32-190010
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  • Size:
    50 µg
    Quantity:
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      • Overview

        • Angiotensin-converting enzyme2 (ACE2) is an ectoenzyme (carboxypeptidase) with an extracellular catalytic domain that predominantly localizes at the plasma membrane and is thereby able to hydrolyze circulating peptides. ACE2 has approximately 42% sequence identity with ACE, and its cytoplasmic and transmembrane domains show 48% homology to the protein collectrin that plays a critical role in the amino acid absorption of the kidney. ACE2 converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. ACE2 is involved in the regulation of systemic blood pressure and has direct effects on cardiac functions. It is expressed predominantly in endothelial cells of the lung, gut, heart and kidney. ACE2 together with the protease TMPRSS2 acts as a functional receptor for SARS coronavirus as well as for the new highly pathogenic coronavirus, 2019-nCoV/SARS-CoV-2, which is cause for pneumonia COVID-19.

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      • Properties
        • Protein Name
          SARS Receptor; Angiotensin-converting Enzyme 2; ACEH; Metalloprotease MPROT15; SARS-CoV-2 Receptor
          Source
          HEK293 cells
          Type
          Recombinant Proteins
          Purification
          ≥95% (SDS-PAGE)
          Formulation
          1mg/ml after reconstitution. Reconstitute with 50µl endotoxin-free water.
          Storage
          After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles. For maximum product recovery after thawing, centrifuge the vial before opening the cap. Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

          More Information

          UniProt
          Q9BYF1

          * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

      • Applications
        • Application
          Functional Assay

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