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Overview
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Calculated MW: 12 kDa/27 kDa/30 kDa/43 kDa/55-70 kDa
Observed MW: 55 kDaPlease contact us at for specific academic pricing.
Background
The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms.
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