Name: HLA-DRB4 Polyclonal Antibody (0.84 mg/mL) for WB, ELISA
Price: 253.00 USD

Overview
- Calculated MW: 30 kDa
  Observed MW: Refer to figures
  Gene Accession: BC005312
  
  Please contact us at for specific academic pricing.
  
  Background
  
  HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Fusion protein of human HLA-DRB4
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  0.84 mg/mL
  
  Antigen
  
  DR 4, DR beta 4 chain, DR4, DRB1 transplantation antigen , DRB4, DRB4, HLA class II histocompatibility antigen, HLA class II histocompatibility antigen DR beta 4 chain , HLA-DRB4, Human leucocyte antigen DRB4 , Leukocyte antigen , Major histocompatibility complex class II DR beta 4 , MHC class II antigen DRB4, MHC class II antigen HLA DR beta , MHC class2 antigen , MHC HLA DR-beta chain (UniProt:P13762)
  
  * For reference only.

Applications

Application

WB; ELISA

Application	Dilutions
WB	1:500-1:2000
ELISA	1:5000-1:10000

HLA-DRB4 Polyclonal Antibody (0.84 mg/mL) for WB, ELISA

HLA-DRB4 Polyclonal Antibody (0.84 mg/mL) for WB, ELISA

Background

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