Name: HLA-DOB Polyclonal Antibody (1.2 mg/mL) for WB, IHC, ELISA
Price: 253.00 USD

Overview
- Calculated MW: 31 kDa
  Observed MW: Refer to figures
  Gene Accession: NP002111
  
  Please contact us at for specific academic pricing.
  
  Background
  
  HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. HLA-DOB (Major Histocompatibility Complex, Class II, DO Beta) is a Protein Coding gene. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding and MHC class II receptor activity. An important paralog of this gene is HLA-DRB1.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human
  
  Immunogen
  
  Synthetic peptide of human HLA-DOB
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1.2 mg/mL
  
  Antigen
  
  HLA-DOB, HLA class II histocompatibility antigen, DO beta chain, MHC class II antigen DOB (UniProt:P13765)
  
  * For reference only.

Applications

Application

WB; IHC; ELISA

Application	Dilutions
WB	1:500-1:2000
IHC	1:30-1:150
ELISA	1:5000-1:10000

HLA-DOB Polyclonal Antibody (1.2 mg/mL) for WB, IHC, ELISA

HLA-DOB Polyclonal Antibody (1.2 mg/mL) for WB, IHC, ELISA

Background

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