HLA-B Polyclonal Antibody

HLA-B Polyclonal Antibody

Catalog Number:
A001506275RED
Mfr. No.:
RD217921A
Price:
$253
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      • Overview
        • Calculated MW: 40 kDa
          Observed MW: Refer to figures
          Gene Accession: NP005505

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          Background

          HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human
          Immunogen
          Synthetic peptide of human HLA-B
          Purification
          Antigen affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          0.9 mg/mL
          Antigen
          1B07, AS, B-4901, B-7 alpha chain, HC class I antigen SHCHA, HLA class I histocompatibility antigen, HLA class I histocompatibility antigen, B alpha chain, HLA-B, HLA-B histocompatibility type, HLAB, leukocyte antigen class I-B, major histocompatibility complex, class I, B, MHC class 1 antigen, MHC class I antigen B*7, MHC class I antigen HLA-B alpha chain, MHC class I antigen HLA-B heavy chain, MHC Class I HLA heavy chain, MHC class I molecule, MHC HLA-B cell surface glycoprotein, MHC HLA-B transmembrane glycoprotein, SPDA1 (UniProt:P01889)

          * For reference only.

      • Applications
        • Application
          WB; IHC; ELISA
        • Application Dilutions
          WB 1:500-1:2000
          IHC 1:30-1:150
          ELISA 1:5000-1:10000

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