HIV DNA Real-TM PCR Kit

HIV DNA PCR kit
Real Time Amplification test for detection of HIV proviral DNA

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Background

HIV-infection diagnostics in children born from HIV-infected mothers is difficult due to the fact that mother antibodies to HIV persist in such children blood for a long time. But not every child born from the infected mother is infected with HIV, in spite of the fact that children are subjected to high risk of HIV infection in the intrauterine period, during the delivery and breast feeding. If no preventive measures are taken, the risk of mother-to-child HIV transmission in children makes 20-45 percent. Today effective measures intended at prevention of vertical HIV transmission can reduce risk to 1-2 percent.
The problem of earlier HIV-infection diagnostics in newborns was solved several years ago with development of molecular-genetic methods that allow detection of HIV genome fragments in the peripheral blood at early infection stages. The evidence was obtained that the HIV provirus DNA is determined by the age of one month in the majority of children and practically in all - by the age of 6 months. Based on these data it is recommended to conduct the polymerase chain reaction (PCR) for HIV provirus DNA for the first time within 48 hours after birth and on the 6-8th week of the child life irrespective of the result of the first examination. The final decision about HIV-infection presence in child is made not later than the age of 6 months of the child.