HIPK3 Polyclonal Antibody

HIPK3 Polyclonal Antibody

Catalog Number:
A001507305RED
Mfr. No.:
RD219326A
Price:
$253
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      • Overview
        • Gene Accession: NP001041665

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          Background

          Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

      • Properties
        • Host
          rabbit
          Antibody Type
          polyclonal
          Isotype
          IgG
          Reactivity
          human; mouse; rat
          Immunogen
          Synthetic peptide of human HIPK3
          Purification
          Antigen affinity purification
          Conjugate
          Unconjugated
          Formulation
          PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
          Storage
          Store at -20°C. Avoid freeze-thaw cycles.
          Concentration
          0.6 mg/mL
          Antigen
          Androgen receptor interacting nuclear protein kinase, Androgen receptor-interacting nuclear protein kinase, ANPK, DYRK6, Fas interacting serine/threonine protein kinase, Fas-interacting serine/threonine-protein kinase, FIST, FIST3, Hipk3, HIPK3, homeodomain interacting protein kinase 3, Homeodomain-interacting protein kinase 3, Homolog of protein kinase YAK1, PKY, RP24 297H17.5, YAK1 (UniProt:Q9H422)

          * For reference only.

      • Applications
        • Application
          IHC; ELISA
        • Application Dilutions
          IHC 1:50-1:300
          ELISA 1:5000-1:10000

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