High Mannose Glycan Standard Library

A mixture of oligomannose glycan standards, with over 90% purity as assessed by HPLC. The high mannose glycans included in the mixture is M5, M6, M7, M8 and M9.

Our new High Mannose Glycan Standard Library is a test standard used both in FDA- and EMEA-approved assays worldwide and also with N-glycan analysis of biological samples for precision medicine. Specifically, this library can be used as a reference standard for high mannose glycans typically monitored in the manufacturing of biotherapeutics. It can also be implemented as a process control to assess the performance of a glycan labelling protocol and/or a system suitability standard for the analytical platform.

The use of standards is part of the guidelines listed in the ICH Topic Q6B Specifications: Test Procedures and Acceptance Criteria for biotechnological/Biological Products. They are beneficial for biotherapeutics development, testing of biosimilars and supporting regulatory submissions.

Biopharmaceutical applications: - Quality control half-life monitoring of biotherapeutics (e.g. Monoclonal Antibodies). - Identifying truncated glycosylation that indicates manufacturing issues affecting cell culture health.

This library combines six oligomannose N-glycan oligosaccharides extracted from porcine thyroglobulin and qualified by MS, HPLC and NMR analysis to meet the high purity and quality standards required by advanced analytical techniques.

MAN-9 – oligomannose N-glycan with 9 mannose residues
MAN-8 – oligomannose N-glycan with 8 mannose residues
MAN-7 – oligomannose N-glycan with 7 mannose residues
MAN-6 – oligomannose N-glycan with 6 mannose residues
MAN-5 – oligomannose N-glycan with 5 mannose residues

Please contact us at for specific academic pricing.