Name: Hemin chloride
Price: 279.00 USD

- Overview
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    Background
    
    Hemin chloride is an oxidized form of heme that inhibits eukaryotic translation initiation factor 2α kinase 1 (eIF2αK1), a repressor of eIF-2α [1].
    The eukaryotic initiation factor 1 (eIF1) plays an important role in translation start site specificity. The eIF2α is a key target in translational regulation. Phosphorylation of eIF2α on Ser51 converts eIF2 from a substrate to a competitive inhibitor of its exchange factor, eIF2β[2].
    In vitro: The addition of hemin (30 μM) depressed the extent of incorporation of phosphate into eIF-2β by about 50% [1]. Concentrations of 25 μM hemin significantly decreased the rate of incorporation of phosphate into eIF-2α. Concentrations of hemin ranged from 20 to 40 μM maintained an optimal rate of protein synthesis in cell lysates [1].
    In vivo: In mice, pretreated with an intraperitoneal injection of hemin displayed a marked induction of HO-1. In hemin-treated mice, thrombus formation was delayed, and the delay was completely blunted by tin protoporphyrin-IX [3].
    
    [1] Tahara S M, Traugh J A, Sharp S B, et al. Effect of hemin on site-specific phosphorylation of eukaryotic initiation factor 2[J]. Proceedings of the National Academy of Sciences, 1978, 75(2): 789-793.
    [2] Sonenberg N, Dever T E. Eukaryotic translation initiation factors and regulators[J]. Current opinion in structural biology, 2003, 13(1): 56-63.
    [3] Lindenblatt N, Bordel R, Schareck W, et al. Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo[J]. Arteriosclerosis, thrombosis, and vascular biology, 2004, 24(3): 601-606.
- Properties
  - Alternative Name
    
    (SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,8-dipropanoato(4-)-κN21, κN22, κN23, κN24]-ferrate(2-), dihydrogen
    
    CAS Number
    
    16009-13-5
    
    Molecular Formula
    
    C34H30ClFeN4O4·2H
    
    Molecular Weight
    
    652.0
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    Purity ≥96.00%
    
    Solubility
    
    ≥26.5 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
    
    Storage
    
    Store at 2-8°C
    
    * For Research Use Only

Hemin chloride

Hemin chloride

Background

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