Helicobacter pylori Real-TM PCR Kit

Real Time Amplification kit test for the qualitative detection jf Helicobacter pylori

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Background

Helicobacter pylori is a gram-negative bacillus responsible for one of the most common infections found in humans worldwide. H. pylori organisms are spiral-shaped gram-negative bacteria that are highly motile because of multiple unipolar flagella. H pylori inhabits the mucus adjacent to the gastric mucosa. Cytotoxin-associated antigen (CagA) is probably the most important virulence factor in H pylori. Translocating the CagA protein into the gastric epithelial cells causes rearrangement of the host cytoskeleton and alters cell signaling and perturbs cell cycle control. Furthermore, CagA-positive strains are known to induce the expression of a DNA-editing enzyme, which leads to accumulation of mutations in the tumor suppressor p53 H. pylori recognized to be associated closely with antral gastritis (gastric and duodenal ulcers in adults and children) and malignancy, specifically gastric lymphoma and adenocarcinoma. H. pylori has been associated with iron-deficiency anemia. The 2 main hypotheses that potentially explain this relation are (1) sequestration of iron due to antral H pylori infection and (2) decreased non-heme iron absorption caused by hypochlorhydria.