Name: GT2-Oligosaccharide
Price: Inquiry

- Overview
  - GT2 oligosaccharide (free acid) has a core trisaccharide structure (GalNAcβ1,4Galβ1,4Glc) with three sialic acid residues (NeuAc) linked α2,8/α2,8/α2,3 to the inner galactose residue (Ledeen, 2009). GT2 oligosaccharide is the carbohydrate moiety in the GT2 ganglioside. A key role has been reported for gangliosides, such as, GT1b and GT2 as modulators in the interaction between microglia (resident cells of the brain that regulate brain development) and brain tumors. It is possible that they will be important targets for therapeutical intervention in the near future (Daniele, 2020). In addition, C-series gangliosides, such as GT3, GT2, GQ1c, and CP1c are expressed in normal pancreatic tissue but are practically lost in the pancreas of diabetic animals (Saito, 1999).
    
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- Properties
  - Categories
    
    Ganglioside Oligosaccharides and Gangliosides
    
    Alternative Name
    
    GalNAcb1-4(Neu5Aca2-8Neu5Aca2-8Neu5Aca2-3)Galb1-4Glc
    
    Molecular Formula
    
    C53H83N4O40Na3
    
    Molecular Weight
    
    1,485.2 g/mol
    
    Note
    
    There is no hazardous surcharge associated with this product.
    There is no special packaging charge associated with this product.
    
    * For research use only. Not for human or veterinary use
- Reference
  - Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J) pp 495-516, Wiley-VCH, Weinheim
    Daniele et al (2020) Brain Cancer-Activated Microglia: A Potential Role for Sphingolipids, Current Medicinal Chemistry, 27(24), 4039-4061.
    Saito (1999) A specific loss of c-series gangliosides in pancreas of streptozotocin-induced diabetic rats, Life Sciences, 64(20), 1803-1810,

GT2-Oligosaccharide

GT2-Oligosaccharide

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