Name: GSTM1 Polyclonal Antibody (1mg/mL) for WB, IHC, IF
Price: 326.00 USD

Overview
- Calculated MW: 43kDa
  Observed MW: 50kDa
  
  Please contact us at for specific academic pricing.
  
  Background
  
  Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present,eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha,kappa,mu,omega,pi,sigma,theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds,including carcinogens,therapeutic drugs,environmental toxins and products of oxidative stress,by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers,likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; mouse; rat
  
  Immunogen
  
  Recombinant Mouse GSTM1 protein expressed by E.coli
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.02% sodium azide,50% glycerol pH 7.4
  
  Storage
  
  Store at -20°C Valid for 12 months. Avoid freeze-thaw cycles.
  
  Concentration
  
  1mg/mL
  
  Antigen
  
  Glutathione S-transferase Mu 1, EC:2.5.1.18, GST 1-1, GST class-mu 1, Glutathione S-transferase GT8.7, pmGT10, Gstm1 (UniProt:P10649)
  
  * For reference only.