Name: GSK-LSD1 2HCl
Price: 196.00 USD

- Overview
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    Background
    
    GSK-LSD1 2HCl is a selective inhibitor of LSD1 with IC50 value of 16 nM [1]. Lysine (K) -specific demethylase 1A (LSD1) is a flavin-dependent histone demethylase that demethylates mono- and di-methylated lysines and plays an important role in oocyte growth, embryogenesis and tissue-specific differentiation. LSD1 plays a role in acute myeloid leukemia (AML). GSK-LSD1 2HCl irreversibly inhibited LSD1 with IC50 value of 16 nM and is > 1000 fold selective over LSD2, MAO-A and MAO-B, which were related to FAD utilizing enzymes. In cancer cell lines, GSK-LSD1 2HCl changed gene expression with average EC50 value < 5 nM and inhibited cells growth with average EC50 value < 5 nM. GSK-LSD1 2HCl (10 ?M) inhibited human recombinant dopamine transporter, 5-HT1A and 5-HT transporter by 39%, 49% and 74%, respectively. And no activity against other 55 recombinant receptors (GPCR, transporters, ion channels). GSK-LSD1 2HCl can be used as a chemical probe and a part of the SGC epigenetics [1].
- Properties
  - Alternative Name
    
    N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine
    
    CAS Number
    
    2102933-95-7
    
    Molecular Formula
    
    C14H22Cl2N2
    
    Molecular Weight
    
    289.24
    
    Appearance
    
    A solid
    
    Purity
    
    99.95%
    
    Solubility
    
    ≥11.55 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

GSK-LSD1 2HCl

GSK-LSD1 2HCl

Background

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