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GSK 4112

GSK 4112

Catalog Number:
L002372431APE
Mfr. No.:
APE-B7460
Price:
$228
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      • Overview

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          Background

          IC50: 2.3 μMGSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba. Clinical trial: N/A

      • Properties
        • Categories
          Rev-Erbα agonist
          Alternative Name
          tert-butyl 2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate
          CAS Number
          1216744-19-2
          Molecular Formula
          C18H21ClN2O4S
          Molecular Weight
          396.89
          Appearance
          A solid
          Purity
          99.28%
          Solubility
          insoluble in EtOH; insoluble in H2O; ≥11.9 mg/mL in DMSO
          Storage
          Store at -20°C
          SMILES
          ClC1=CC=C(CN(CC2=CC=C([N+]([O-])=O)S2)CC(OC(C)(C)C)=O)C=C1

          * For Research Use Only

    Documents

    COA (Certificate Of Analysis)

    HPLC (Retest)

    NMR (Nuclear Magnetic Resonance)

    MSDS (Material Safety Data Sheet)

    Datasheet

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