Name: GPN1 Recombinant Protein
Price: Inquiry

- Overview
  - GPN1 Human Recombinant produced in E. coli is a single polypeptide chain containing 398 amino acids (1-374) and having a molecular mass of 44.3 kDa. GPN1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. GPN-loop GTPase 1 (GPN1) is a member of the GPN-loop GTPase family. GPN1 is a guanosine triphosphatase enzyme which has a role in DNA repair and may function in activation of transcription. Small GTPases, which share a biochemical mechanism, act as binary molecular switches and function in the cell is nucleocytoplasmic transport of both proteins and RNA. In addition, GPN1 establishs an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein, proposing that it is essential to connect RNA polymerase II to regulators of protein complex formation. GPN1 may also be involved in nuclear localization of XPA.
    
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- Properties
  - Protein Name
    
    GPN-loop GTPase 1, XPA binding protein 1 GTPase, RNA polymerase II associated protein 4, MBD2-interacting protein, MBDin, ATP(GTP)-binding protein, XAB1, ATPBD1A, NTPBP, RPAP4.
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 90% as determined by SDS-PAGE.
    
    Formulation
    
    The GPN1 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 50mM NaCl, 1mM DTT and 10% glycerol.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

GPN1 Recombinant Protein

GPN1 Recombinant Protein

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