Name: GNB3 Recombinant Protein
Price: Inquiry

- Overview
  - GNB3 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 363 amino acids (1-340 a.a) and having a molecular mass of 39.6kDa. GNB3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. GNB3belongs to the WD repeat G protein beta family. GNB3 is an important regulatorof alpha subunit, as well as of certain signal transduction receptor and effector. A single-nucleotide polymorphism (C825T) in GNB3 is linked with essentialhypertension and obesity. In addition, this polymorphism is also linked withthe occurrence of the splice variant GNB3-s, which seems to have increasedactivity. GNB3-s is an example of alternative splicing caused by a nucleotidechange outside of the splice donor and acceptor sites. Further splice variantsmay exist for GNB3, however they have not been fully described. Among thediseases associated with GNB3 are syncope, and aortic coarctation.
    
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- Properties
  - Protein Name
    
    Transducin Beta Chain 3, G Protein, Beta-3 Subunit, GTP-BindingRegulatory Protein Beta-3 Chain, Guanine Nucleotide-Binding ProteinG(I)/G(S)/G(T) Beta Subunit 3, Guanine Nucleotide-Binding ProteinG(I)/G(S)/G(T) Subunit Beta-3, Hypertension Associat
    
    Source
    
    E. coli
    
    Type
    
    Recombinant Proteins
    
    Purification
    
    Greater than 80.0% as determined by SDS-PAGE.
    
    Formulation
    
    GNB3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea.
    
    Storage
    
    Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
    
    * For Research Use Only. Not for use in diagnostic/therapeutics procedures.

GNB3 Recombinant Protein

GNB3 Recombinant Protein

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