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GM3-Ganglioside labelled by NBD ammonium

GM3-Ganglioside labelled by NBD ammonium

Catalog Number:
C003138734BIO
Mfr. No.:
OG09793
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      • Overview

        • GM3-ganglioside NBD (ammonium salt) has a core disaccharide structure (Galβ1,4Glc) with sialic acid linked α2,3 to the galactose residue with nitrobenzoxadiazole (NBD) linked β to position 1 on the reducing terminal glucose residue, in place of the ceramide fatty acid (Ledeen, 2009). Ganglioside GM3 is strongly associated with human tumors, such as, lung, brain, and melanomas, where it is frequently found to be overexpressed. GM3 ganglioside is seen as a possible tumor-associated carbohydrate antigen for cancer immunotherapy (Changping, 2019). GM3 ganglioside is implicated in various other diseases involving chronic inflammation, such as: insulin resistance, leptin resistance, T-cell function, and immune disorders (e.g. allergic asthma). It has also been shown to play an essential role in murine and human auditory systems, and is a common pathological feature of GM3S deficiency is deafness (Inokuchi, 2018).

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      • Properties
        • Categories
          Ganglioside Oligosaccharides and Gangliosides
          Alternative Name
          N-Acetyl-a-D-neuraminic acid)-(2->3)-O-b-D-galactopyranosyl-(1->4)-O-b-D-glucopyranosyl-(1->1)-(2S,3R,4E)-2-N-(7-nitrobenz-2-oxa-1,3 -diazol-4-yl)aminooctanamido-4-octadecene-1,3-diol ammonium salt;aNeu5Ac(2-3)bDGalp(1-4)bDGlcp(1-1)Cer linked 7-nitrob
          Molecular Formula
          C55H90N6O24·H3N
          Molecular Weight
          1,236.36 g/mol
          MDL Number
          MFCD18643209
          Note
          There is no hazardous surcharge associated with this product.
          There is no special packaging charge associated with this product.

          * For research use only. Not for human or veterinary use

      • Reference

        • Ledeen et al (2009) Neurobiology Meets Glycosciences, In: The Sugar Code (Ed: Gabius H. J) pp 495-516, Wiley-VCH, Weinheim
          Changping et al (2019) Ganglioside GM3 and Its Role in Cancer, Current Medicinal Chemistry, 26(16), 2933-2947,
          Inokuchi et al (2018) Chapter Five - Biology of GM3 Ganglioside.
          Schnaar et al (2018) Progress in Molecular Biology and Translational Science, Academic Press, 156,

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