Glucose-6-Phosphate Colorimetric Assay (TBS2103)

Glucose 6-Phosphate dehydrogenase (G6PDH) is a key regulatory enzyme in the first step of the pentose phosphate pathway. In the presence of NADP+ or NAD+, it oxidizes glucose-6-phosphate (G6P) to 6-Phosphogluconolactone (6PG) and NADPH or NADH. It plays a vital role in numerous biosynthetic pathways and is important for preventing oxidative damage. In humans, deficiency is an autosomal hereditary disorder that can result in the depletion of NADPH in red blood cells and increases the risk of hemolytic anemia in situations of oxidative stress. On the other hand, inhibition of G6PDH has been linked to anti-cancer activity by decreasing RNA biosynthesis and increasing the buildup of reactive oxygen species in tumor cells.

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