Glucagon-like Peptide 2, human

Glucagon-like Peptide 2, human
GLP-2
MW: 3766.7
H-His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp-OH
Primary cleavage product of proglucagon in intestinal L cells. Recent studies indicate that GLP-2 has trophic action on the jejenum, ileum and colon. It , or
analogues, should be potential candidates for treating short bowel syndrome.
Orskov C. et al. (1986) Endocrinology 119, 1467;
Buhl T. et al. (1988) J. Biol. Chem. 263, 8621;
Orskov C. et al. (1989) FEBS Letters 247, 193; Drucker D.J. etal. (1996) Proc. Natl. Acad. Sci. USA 93, 7911;
Tsai C.H. et al. (1997) Am. J.Physiol. 272, G662.
500µg
1mg

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