Gastrin-Releasing Peptide, human

Gastrin-Releasing Peptide, human

Catalog Number:
P004440233INV
Mfr. No.:
V28709
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      • Overview
        • Gastrin-Releasing Peptide, human (GRP) is a peptide belonging to the mammalian homolog of bombesin (BBS) class, it functions as a mitogen for multiple cancers, such as neuroblastoma. GRP is a ligand for GRPR (GRP receptor) and is expressed in a subtype of peptidergic dorsal root ganglion neurons. It is not a classical hypothalamic-hypophyseal regulatory hormone since it plays only a perfunctory role in the mediation of pituitary hormone release. GRP functions as an autocrine growth factor for nueroblastoma. It facilitates cell survival in PI3K/AKT (phosphatidylinositol-3-kinase/ v-Akt murine thymoma viral oncogene)-mediated manner and cell proliferation and angiogenesis in neuroblastoma. This peptide is involved in the release of gastrin and the control of gastric acid secretion and motor function. In patients with atopic dermatitis, the serum levels of this peptide are linked with pruritus

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      • Properties
        • Categories
          Peptides
          CAS Number
          93755-85-2
          Molecular Formula
          C130H204N38O31S2
          Molecular Weight
          2859.38
          Purity
          ≥98%
          Storage
          Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
          In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
          Shipping
          Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
          SMILES
          CC(C[C@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC(CNC([C@@H](NC([C@@H]2CCCN2C([C@@H](NC([C@@H]3CCCN3C([C@@H](N)C(C)C)=O)=O)CC(C)C)=O)=O)C)=O)=O)=O)=O)[C@H](O)C)=O)C(C)C)=O)CC(C)C)=O)[C@H](O)C)=O)CCCCN)=O)CCSC)=O)CC4=CC=C(O)C=C4)=O)=O)CCCNC(N)=N)=O)=O)CC(N)=O)=O)CC5=CN=CN5)=O)CC6=CNC7=CC=CC=C67)=O)C)=O)C(C)C)=O)=O)CC8=CN=CN8)=O)C(N[C@H](C(N)=O)CCSC)=O)C

          * For research use only

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