FSB Solution

Amyloidosis, a disease which has been identified as a particular disorder by the Japanese Ministry of Health, is an illness that involves an abnormal protein called amyloid that has a β sheet structure, aggregates in fibers, and is deposited on the outside of internal organs and systems, inhibiting the function of those organs and systems. Disorders among many Japanese include immunocytic amyloidosis (AL amylodosis), responsive AA amyloidsis, familial amyloid polyneuropathy (FAP), and dialysis amyloidsis (DRA). It is estimated that there are hundreds of patients throughout Japan. The proteins that cause amyloidosis can be largely divided into two groups: amylids that are deposited in various organs throughout the body (systemic amyloidosis) such as the disorders listed above, and [ amyloids that are deposited in a particular organ, such as the brain in the case of Alzheimer’s disease (localized amyloidosis). The dye 1-Bromo-2,5-bis(3-carboxy-4-hydroxystyryl)benzene (BSB) has been used for detecting amyloids because of its high affinity with amyloid β peptide (Aβ), the amyloid associated with Alzheimer’s disease.

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