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Overview
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Background
Folinic acid, clinically known as leucovorin, is a ubiquitous member of biological folate pools, usually accounting for 10 ~ 20% of total cellular folates. Folinic acid can reduce methotrexate (MTX)-induced cytogenetic damage, and appears to be an anticlastogenic agent. Folinic acid serves as a rescue agent used alone or in combination with 5-fluorouracil to decrease MTX-induced toxicity.
1. Keshava C, Keshava N, Whong WZ, et al. Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutation Research, 1998, 397(2): 221-228.
2. Iqbal MP, Ahmed M, Umer M, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatrica, 2003, 92(12): 1438-1444.
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