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Overview
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Reactivity: Human CD15/CD34 is use to identify and determine the percentage of myelomonocytic cells and myeloid progenitor cells in erythrocyte lysed whole blood, based on cell-surface antigen expression. CD15 is expressed on more than 95% of mature peripheral blood neutrophils, eosinophils and on a small percentage of circulating monocytes. CD15 is the myeloid type of alpha-3-fucosyltransferase (also designated FUT4), which is distinct from the plasma type of alpha-3-fucosyltransferase (designated FUT5) in that only CD15 creates the 3-fucosyllactosamine epitope on polymorphonuclear cells and monocytes CD34 is a marker for myeloid progenitor cells. CD34 expression is highest on early hematopoietic progenitor cells, decreases as cells mature and is absent on fully differentiated hematopoietic cells. The CD15+/CD34+ phenotype is aberrant in acute myeloidleukemia patients, but is rare in normal bone marrow. Changes in the CD15/ CD34 phenotype may be useful in studying normaland malignant myeloid differentiation Applications: It can be used to study expression of the myeloid leukemias.
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