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Overview
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This antibody reacts with the CD42b-antigen. It reacts with a two chain membrane glycoprotein, GpIb, that forms a non covalent complex with GPIX (CD42a) found on platelets and magakaryocytes. Clone HIP1 antibody inhibits the ristocetin-dependent binding of von Willebrand Factor (vWF) to platelets, ristocetin-induced platelet agglutination and partially inhibits collagen induced aggregation. The GPIb/IX complex serves as the vWF surface receptor involved in the adhesion of platelets to the subendothelium of damaged vascular walls.
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