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Overview
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This antibody reacts with the CD28-antigen, which is expressed on approximately 29 % of CD4+. CD28 mediates cell adhesion trough the two ligands, CD80, expressed on activated B cells. Cross-blooking of CD28 induces T cell activation, suggesting an important role for CD28 in the interaction between B and T cells. This antibody recognizes an homodimeric transmembrane glycoprotein present on most mature T cells, thymocytes and plasma cells.
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