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Overview
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FHL3 Human Recombinant produced in E. Coli is a single,non-glycosylated polypeptide chain containing 303 amino acids (1-280 a.a) andhaving a molecular mass of 33.6kDa. FHL3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Fourand a half LIM domains 3 (FHL3) belongs to a family of proteins containing afour-and-a-half LIM domain, which is a highly conserved double zinc fingermotif. FHL3 has been shown to interact with the cancer developmental regulatorsSMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and thehigh-affinity IgE beta chain regulator MZF-1. FHL3 is involved in tumorsuppression, repression of MyoD expression, and repression of IgE receptorexpression. Two transcript variants encoding different isoforms have been foundfor this gene.
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Overview