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Overview
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FHL2 Human Recombinant produced in E. Coli is a single, non-glycosylated polypeptide chain containing 302 amino acids (1-279 a.a) and having a molecular mass of 34.6kDa. FHL2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Four And A Half LIM Domains 2 (FHL2)belongs to the four-and-a-half-LIM-only protein family. Family members arecomprised of 2 highly conserved, tandemly arranged, zinc finger domains with 4highly conserved cysteines binding a zinc atom in each zinc finger. The FHL2protein is assumed to play a part in the assembly of extracellular membranes. Furthermore, FHL2 is down-regulated during transformation of normal myoblaststo rhabdomyosarcoma cells and the FHL2 functions as a link between presenilin-2and an intracellular signaling pathway.
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Overview