Name: Ferrostatin-1 (Fer-1)
Price: 196.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Ferrostatin-1 is a selective inhibitor of ferroptosis. Ferroptosis is a regulated, oxidative, nanapoptotic cell death, Ferrostatin-1 has been founded as a potent inhibitor of it. Fer-1 can attenuate oxidative, iron-dependent cancer cell death through blocking cystine import and glutathione production. It had been reported to prevent Huntington's disease cellular models to death by inhibiting lipid peroxidation.[1]
- Properties
  - CAS Number
    
    347174-05-4
    
    Molecular Formula
    
    C15H22N2O2
    
    Molecular Weight
    
    262.35
    
    Appearance
    
    A solid
    
    Purity
    
    99.61%
    
    Solubility
    
    insoluble in H2O; ≥9.8 mg/mL in DMSO; ≥99.6 mg/mL in EtOH with ultrasonic
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Jiawen Cui, Qin Zhou, Chintada Nageswara Rao, et al. "4-tert-butylphenol triggers common carp hepatocytes ferroptosis via oxidative stress, iron overload, SLC7A11/GSH/GPX4 axis, and ATF4/HSPA5/GPX4 axis." Ecotoxicol Environ Saf. 2022 Sep 1;242:113944. PMID: 35926411
    2. Tingting Liao, Xia Xu, et al. "DJ-1 upregulates the Nrf2/GPX4 signal pathway to inhibit trophoblast ferroptosis in the pathogenesis of preeclampsia." Sci Rep. 2022 Feb 21;12(1):2934. PMID: 35190654
    3. QING SHI, RUI LIU, et al. "Ferroptosis inhibitor ferrostatin‑1 alleviates homocysteine‑induced ovarian granulosa cell injury by regulating TET activity and DNA methylation." Mol Med Rep. 2022 Apr;25(4):130. PMID: 35169856
    4. Amjad Ali, Jasmin Shafarin, et al. "Co-targeting BET bromodomain BRD4 and RAC1 suppresses growth, stemness and tumorigenesis by disrupting the c-MYC-G9a-FTH1axis and downregulating HDAC1 in molecular subtypes of breast cancer." Int J Biol Sci. 2021 Oct 25;17(15):4474-4492. PMID: 34803511
    5. Zongbo Wei, Caili Hao, et al. "Aging lens epithelium is susceptible to ferroptosis." Free Radic Biol Med. 2021 May 1;167:94-108. PMID: 33722625
    6. Junting Xiao, Shanshan Zhang, et al. "Arsenite induces ferroptosis in the neuronal cells via activation of ferritinophagy." Food Chem Toxicol. 2021 May;151:112114. PMID: 33722599
    7. Binghua Liu, Weiyan Wang, et al. "Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells." Cell Death Dis. 2021 Mar 3;12(3):230. PMID: 33658488
    8. Zhuo Sun, Yidan Cao, et al. "Antiangiogenic effect of arsenic trioxide in HUVECs by FoxO3a‐regulated autophagy." J Biochem Mol Toxicol. 2021 Feb 16;e22728. PMID: 33592126
    9. Xinzhi Yang, Jiangang Liu, et al. "miR-18a promotes glioblastoma development by down-regulating ALOXE3-mediated ferroptotic and anti-migration activities." Oncogenesis. 2021 Feb 12;10(2):15. PMID: 33579899
    10. Ali Ghoochani, En-Chi Hsu, et al. "Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer." Cancer Res. 2021 Mar 15;81(6):1583-1594. PMID: 33483372
    11. Qi Wang, Yaxun Guo, et al. "RNA binding protein DAZAP1 promotes HCC progression and regulates ferroptosis by interacting with SLC7A11 mRNA." Exp Cell Res. 2021 Feb 1;399(1):112453. PMID: 33358859
    12. Xia Qin, Qianghu Tang, et al. "Zinc Oxide Nanoparticles Induce Ferroptotic Neuronal Cell Death in vitro and in vivo." Int J Nanomedicine. 2020 Jul 27;15:5299-5315. PMID: 32884256
    13. Tianshu Wu, Xue Liang, et al. "Induction of ferroptosis in response to graphene quantum dots through mitochondrial oxidative stress in microglia." Particle and Fibre Toxicology volume 17, Article number: 30 (2020).11 July 2020.
    14. Meng P, Zhang S, et al. "Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis." Ecotoxicol Environ Saf. 2020;194:110360. PMID: 32151864
    15. Hu Z, Zhang H, et al. "VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis." Cell Death Dis. 2020;11(1):73. Published 2020 Jan 29. PMID: 31996668
    16. Zhou HH, Chen X, et al. "Erastin Reverses ABCB1-Mediated Docetaxel Resistance in Ovarian Cancer." Front Oncol, 9, 1398 2019 Dec PMID: 31921655
    17. Xiaohong Zhang, Xueshuang Xing, et al. "Ionizing radiation induces ferroptosis in granulocyte-macrophage hematopoietic progenitor cells of murine bone marrow." Int J Radiat Biol , 1-35 2020 Jan 6. PMID: 31906761
    18. Wang H, Liu C, et al. "Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells." Biochem Biophys Res Commun. 2019 Dec 7. pii: S0006-291X(19)32315-0. PMID: 31822343

Ferrostatin-1 (Fer-1)

Ferrostatin-1 (Fer-1)

Background

We Also Recommend

NLG919

PF-3845

URB597