Name: Fatostatin A
Price: 201.00 USD

- Overview
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    Background
    
    Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP), which can inhibit the activation of SREBP-1 and SREBP-2[1].
    Fatostatin A (0.1-1 μM; 3 days) inhibits the androgen-independent proliferation of prostate cancer cell in a manner independent of the known IGF1 signaling pathway. Fatostatin A inhibits insulin-induced fat formation in 3T3-L1 cells[2].
    Fatostatin A (30 mg/kg; 150 mL; i.p.; daily for 28 days) prevents obese ob/ob mice from increasing their weight, blood sugar, and liver fat accumulation, even if they do not control the food intake of mice[1].
    
    [1]. Kamisuki S, et al. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009, 16(8): 882-92.
    [2]. Choi Y, et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003, 278(9): 7320-4.
- Properties
  - Alternative Name
    
    2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole hydrobromide
    
    CAS Number
    
    298197-04-3
    
    Molecular Formula
    
    C18H18N2S·HBr
    
    Molecular Weight
    
    375.33
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥19.76 mg/mL in DMSO; ≥5.02 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Fatostatin A

Fatostatin A

Background

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