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Overview
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Calculated MW: 12kDa
Observed MW: 14kDaPlease contact us at for specific academic pricing.
Background
Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediate apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains,leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance,in the antigen-stimulated suicide of mature T-cells,or both. The molecular mass of native Fas is 38 kDa,the high molecular weight form (40-55 kDa) of Fas is due to glycosylation.
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