Name: Exo1
Price: 196.00 USD

- Overview
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    Background
    
    IC50: about 20 μM for exocytosisExo1 is a chemical inhibitor of the exocytic pathway.The development of a cellular organism is mainly controlled at the transcriptional level but it was also shown to require the transport of membrane and proteins via the exocytic pathway to the plasma membrane and the extracellular medium.In vitro: A Previous study using phenotypic screen to search for drug-like molecules that could interfere with specific steps in membrane traffic. Screening resulted in the identification of Exo1, which could induce a rapid collapse of the Golgi to the endoplasmic reticulum, therefore inhibiting the traffic emanating from the endoplasmic reticulum acutely. In addition, similar to Brefeldin A (BFA), Exo1 could induce the quick release of ADP-ribosylation factor (ARF) 1 from Golgi membranes but had minimal effect on the organization of the trans-Golgi network. These data suggested that Exo1 acted by a different mechanism from BFA. However, unlike BFA, Exo1 could not induce the ADP-ribosylation of CtBPBars50 and could not interfere with the activity of guanine nucleotide exchange factors neither. Thererfore, Exo1 allowed the fatty acid exchange activity of Bars50 to be distinguished from ARF1 activity [1]. In vivo: Currently, there is no animal data reported. Clinical trial: Up to now, Exo1 is still in the preclinical development stage.
- Properties
  - Alternative Name
    
    methyl 2-(4-fluorobenzamido)benzoate
    
    CAS Number
    
    75541-83-2
    
    Molecular Formula
    
    C15H12FNO3
    
    Molecular Weight
    
    273.26
    
    Appearance
    
    A white to off-white solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; insoluble in EtOH; ≥27.2 mg/mL in DMSO
    
    Storage
    
    Store at RT
    
    * For Research Use Only

Exo1

Exo1

Background

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