Name: ETP-46464
Price: 260.00 USD

- Overview
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    Background
    
    ETP-46464 is a potent and selective inhibitor for ATR (IC50 = 25 nM).
    ATR (ATM- and Rad3-related) is a member of PIKK (phosphatidylinositol 3-kinase-like kinases) that regulates the DNA damage response pathways. It is a DNA damage sensor that is activated upon genotoxic stresses (e.g. ionizing radiation, UV radiation and DNA replication stalling) and phosphorylates its downstream substrates (e.g. p53, BRCA1 and CHEK1).
    ETP-46464 abolished the G2/M checkpoint. It caused the presence of micronuclei or completely fragmented nuclei in cells under ionizing radiation. Cells treated simultaneously with hydroxyurea and ETP-46464 exhibited elevated ATM and Chk2 phosphorylation. In U2OS cells, ETP-46464 promoted the breakage of stalked replication forks. [1]
- Properties
  - Alternative Name
    
    2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile
    
    CAS Number
    
    1345675-02-6
    
    Molecular Formula
    
    C30H22N4O2
    
    Molecular Weight
    
    470.52
    
    Appearance
    
    A solid
    
    Purity
    
    98.57%
    
    Solubility
    
    ≥16.13 mg/mL in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only