Name: Etodolac
Price: 180.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Etodolac (Lodine) is a selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 53.5 nM. Etodolac, a non-steroidal anti-inflammatory drug (NSAID), has been reported to treat osteoarthritis and rheumatoid arthritis.Etodolac was able to abolish the cell size decrease and block caspase-3/7 activity in TNFα-induced isolated rabbit articular chondrocytes [1]. However, studies have shown that etodolac at 24h could induce cell death in human malignant rhabdoid tumor cells (FRTK-1) in a dose-dependent manner. Additionally, etodolac has shown to increase caspase-8, -9 and -3 activity 3 at 24 or 48 h in FRTK-1 [2].
    
    [1] Kumagai K1, Kubo M, Imai S, Toyoda F, Maeda T, Okumura N, Matsuura H, Matsusue Y.The COX-2 selective blocker etodolac inhibits TNFα-induced apoptosis in isolated rabbit articular chondrocytes. Int J Mol Sci. 2013 Sep 30;14(10):19705-15.
    [2] Hakozaki M1, Hojo H, Kikuchi S, Abe M. Etodolac, a selective cyclooxygenase-2 inhibitor, induces apoptosis by activating caspases in human malignant rhabdoid tumor cells (FRTK-1). Oncol Rep. 2007 Jan;17(1):169-73.
- Properties
  - Alternative Name
    
    2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid
    
    CAS Number
    
    41340-25-4
    
    Molecular Formula
    
    C17H21NO3
    
    Molecular Weight
    
    287.35
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in H2O; ≥14.37 mg/mL in DMSO; ≥77.7 mg/mL in EtOH
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only

Etodolac

Etodolac

Background

We Also Recommend

Ketoprofen

Ketorolac tromethamine salt