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Overview
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Potent and selective μ opioid receptor agonist.
Endomorphin-2 is an endogenous peptide with extremely high affinity and selectivity for μ-opioid receptors, with Ki values of 0.69, 9233 and 5240 nM for μ, δ and κ receptors respectively. Endomorphin-2 is one of the two endomorphins and along with endomorphin-1 produces analgesia in animals, but whereas endomorphin-1 is more prevalent in the brain, endomorphin-2 is more prevalent in the spinal cord.
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Overview