Endo-Porter Aqueous

Endo-Porter aqueous in solution with 0.3 M mannitol for DMSO-free delivery into the cytosol of cultured cells.

Endo-Porter is a novel peptide* explicitly designed to deliver substances into the cytosol of cells by an endocytosis-mediated process that avoids damaging the plasma membrane of the cell. Unlike the toxic delivery mechanisms used by other available peptide and lipid based delivery reagents, this endocytotic mechanism prevents the toxicity resulting from loss of vital cell contents.

Endo-Porter in DMSO is our highest efficacy reagent for delivery to cultured cells. However, since even low concentrations of DMSO can trigger responses in some cell types, we provide Endo-Porter aqueous as a DMSO-free alternative.

Endo-Porter can deliver high concentrations of cargo exceeding 70KD into both adherent and non-adherent cells, as shown by detailed studies with FITC-anti-actin antibody (Sigma F-3046, 50Kd) and fluorescent high-molecular weight dextrans (Invitrogen / Molecular Probes D-1823, 70 kD). Endo-Porter
requires no interaction with the cargo to be delivered and, by permeabilizing the endosomal membrane, Endo-Porter allows cargo that is co-endocytosed to enter the cytosol. Unlike the many delivery reagents that claim effectiveness in the presence of serum, Endo-Porter aqueous works well in standard 10% serum.

Endo-Porter delivers substances such as peptides, proteins, or antibodies and is excellent for delivering Morpholino antisense oligos as well!

Please contact us at for specific academic pricing.