Name: EIPA
Price: 199.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    EIPA is a TRPP3 channel inhibitor with an IC50 value of 10.5 μM, EIPA also inhibits Sodium-hydrogen exchangers (NHE) and macropinocytosis[1].
    In Chinese hamster ovary cells, EIPA is a Na+/Ca2+ exchange (NCX) inhibitor that inhibits ET-1-induced continuous increase of intracellular Ca2+ concentration. In Xenopus oocytes, EIPA can rapidly and reversibly block calcium ion-activated TRPP3 channel activation at -50mV and other membrane potentials[2].
    
    [1]. Dai X Q, et al. Inhibition of TRPP3 channel by MK-870 and analogs. Mol Pharmacol, 2007, 72(6): 1576-85.
    [2]. Horinouchi T, Miyake Y, Nishiya T, et al. Functional Role of Na+/H+ Exchanger in Ca2+ Influx Mediated via Human Endothelin Type A Receptor Stably Expressed in Chinese Hamster Ovary Cells. Journal of Pharmacological Sciences, 2008, 107(4): 456-459.
- Properties
  - Alternative Name
    
    3-amino-6-chloro-N-(diaminomethylene)-5-(ethyl(isopropyl)amino)pyrazine-2-carboxamide
    
    CAS Number
    
    1154-25-2
    
    Molecular Formula
    
    C11H8ClN7O
    
    Molecular Weight
    
    299.76
    
    Appearance
    
    A crystalline solid
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only
- Reference
  - 1. Jia Wen, Xiuge Gao, et al. "Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle." Pharmaceutics. 2021 Feb 25;13(3):303. PMID:33669090
    2. Zhang Q, Yang H, et al. "Nanostructured lipid carriers with exceptional gastrointestinal stability and inhibition of P-gp efflux for improved oral delivery of tilmicosin." Colloids Surf B Biointerfaces. 2019 Nov 17:110649. PMID:31767412
    3. Li Y, Yang B, et al. "Oral delivery of imatinib through galactosylated polymeric nanoparticles to explore the contribution of a saccharide ligand to absorption." Int J Pharm. 2019 Jul 9;568:118508. PMID:31299337
    4. Liu W, Zhang L, et al. "Alpl prevents bone ageing sensitivity by specifically regulating senescence and differentiation in mesenchymal stem cells." Bone Res. 2018 Sep 11;6:27. PMID:30210899
    5. Siu FY, Ye S, et al. "Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity." Int J Nanomedicine. 2018 Jul 13;13:4133-4144. PMID:30038494
    6. Gao W, Ye G, et al. "Transferrin receptor-targeted pH-sensitive micellar system for diminution of drug resistance and targetable delivery in multidrug-resistant breast cancer." Int J Nanomedicine. 2017 Feb 7;12:1047-1064. PMID:28223798

EIPA

EIPA

Background

We Also Recommend

AM 1172

Benzamil

Phenamil