Name: DUT Polyclonal Antibody (1.2 mg/mL) for IHC, ELISA
Price: 253.00 USD

Overview
- Gene Accession: BC033645
  
  Please contact us at for specific academic pricing.
  
  Background
  
  This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; rat
  
  Immunogen
  
  Fusion protein of human DUT
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1.2 mg/mL
  
  Antigen
  
  Deoxyuridine 5' triphosphate nucleotidohydrolase, nuclear isoform, Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial, Deoxyuridine triphosphatase, dut, DUT, dUTP nucleotidohydrolase, dUTP pyrophosphatase, dUTPase, FLJ20622 (UniProt:P33316)
  
  * For reference only.

Applications

Application

IHC; ELISA

Application	Dilutions
IHC	1:50-1:300
ELISA	1:5000-1:10000

DUT Polyclonal Antibody (1.2 mg/mL) for IHC, ELISA

DUT Polyclonal Antibody (1.2 mg/mL) for IHC, ELISA

Background

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