DSP

- Overview
  - DSP is a cross-linking reagent reacting the amino groups with each other. Since DSP has at both ends ofthe molecule N-hydroxysuccinimide active ester to react selectively with the amino group, it can be conjugated a carrier protein to simple hapten or preparation labeled enzyme. BS3 takes achemical structure having analkyl chain to the linker moiety. Meanwhile, DTSSP and DSP is capable of cleavage of the disulfide-introduced linker site that is easily reduced by the reducing agent. Further, since the active ester group having a sulfonic acid group is introduced to DTSSP and BS3, it may be carried out labeling reaction without using an organic solvent such as DMSO or DMF.
    
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- Properties
  - Categories
    
    Cross-Linker
    
    Alternative Name
    
    Dithiobis(succinimidyl propionate)
    
    CAS Number
    
    57757-57-0
    
    Molecular Weight
    
    C14H16N2O8S2=404.42
    
    Appearance
    
    White to almost white powder
    
    Purity
    
    (HPLC): ≧95.0 %
    
    Storage
    
    0-5°C
    
    * For research use only
- Reference
  - 1) P. F. Pilch and M. P. Czech, "Interaction of Cross-linking Agents with the Insulin Effector System of Isolated Fat Cells", J. Biol. Chem., 1979, 254(9), 3375.
    2) M. A. Gosselin, W. Guo and R. J. Lee, "Efficient Gene Transfer Using Reversibly Cross-linked Low Molecular Weight Polyethylenimine", Bioconjugate Chem., 2001, 12, 989.
    3) M. A. Gosselin, W. Guo and R. J. Lee, "Incorporation of Reversibly Cross-linked Polyplexes into LPDII Vectors for Gene Delivery", Bioconjugate Chem., 2002, 13, 1044.
    4) P.-Y. Zeng, C. R. Vakoc, Z.-C. Chen, G. A. Blobel and S. L. Berger, "In vivo dual Cross-linking for Identification of Indirect DNA-Associated Proteins by Chromatin Immunoprecipitation", BioTechniques, 2006, 41(6), 694.
    5) S. Santra, C. Kaittanis, O. J. Santiesteban and J. M. Perez, "Cell-Specific, Activatable, and Theranostic Prodrug for Dual-Targeted Cancer Imaging and Therapy", J. Am. Chem. Soc., 2011, 133, 16680.

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DSP

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