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DMT-butane-Diol phosphoramidite

DMT-butane-Diol phosphoramidite

Catalog Number:
NAS1056385CHE
Mfr. No.:
CLP-9775
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      • Overview

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      • Properties
        • Categories
          Spacer Amidites
          Molecular Formula
          C34H45N2O5P
          Molecular Weight
          592.710
          Shipping
          This material is sensitive to heat and moisture. It requires the fastest shipment possible.
      • Applications
        • Application Description
          The DMTr-butane-Diol phosphoramidite (Catalog # CLP-9775):

          The DMTr-butane-Diol phosphoramidite introduces the butane diol moiety (single or multiple units) into an oligonucleotide. The butanediol spacer has been incorporated in oligonucle­otides consisting of 2’,5’-RNA and DNA segments to produce oligonucleotide chimeras that catalyze selective cleavage of RNA in human cells.1,2 The corresponding CPG is also available to incorporate this unit at the 3’-end of an oligo.

          References:

          1. Maitra, R. K.; Li, G.; Xiao, W.; Dong, B.; Torrence, P. F.; Silverman, R. H. J. Biol. Chem. 1995, 270, 15071.

          2. Lesiak, K.; Khamnei, S.; Torrence, P. F. Biocon. Chem. 1993, 4, 467.

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