Name: DL-threo-2-methylisocitrate sodium
Price: 1014.00 USD

- Overview
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    Background
    
    DL-threo-2-methylisocitrate sodium is a substrate of isocitratelyase 1(ICL1).
    ICL1 had dual activity for both threo-D(s)L(s)-isocitrate (ICA) and DL-threo-2-methylisocitrate (MICA). Using Michaelis-Menten non-linear least squares fit, the Km of purified recombinant ICL1 for threo-D(s)L(s)-isocitrate (ICA) was determined to be 188 mM with akcatof 5.24 s-1 .The Km of ICL2 for MICA was greater than 15 mM which was too high to be determained accurately due to the limitations of the solubility of MICA. The Kcat/Km for ICL1, a measureforcatalyticefficiency, was 2.79 × 104 M-1 s-1 and 1.74 ×103 M-1 s-1, for ICA and MICA respectively.
    
    Reference:
    [1]. Gould TA1,van de Langemheen H,Muoz-Elías EJ,McKinney JD,Sacchettini JC. Dual role of isocitratelyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.Mol Microbiol.2006 Aug;61(4):940-7.
- Properties
  - Categories
    
    Substrate of isocitrate lyase 1(ICL1)
    
    Alternative Name
    
    sodium (2R,3S)-3-hydroxybutane-1,2,3-tricarboxylate
    
    Molecular Formula
    
    C14H14Na6O14
    
    Molecular Weight
    
    544.19
    
    Purity
    
    98.00%
    
    Solubility
    
    Soluble in DMSO
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C[[email protected]](C([O-])=O)(O)[[email protected]@](C([O-])=O)([H])CC([O-])=O.C[[email protected]](C([O-])=O)(O)[[email protected]@](C([O-])=O)([H])CC([O-])=O.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
    
    * For Research Use Only