Name: DL-α-Difluoromethylornithine (hydrochloride hydrate)
Price: 180.00 USD

- Overview
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    Background
    
    DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase.Ornithine decarboxylase catalyzes the decarboxylation of ornithine to form putrescine, which is the committed step in polyamine synthesis.DFMO inhibited the polyamine synthesis process and displayed antiangiogenic and cytostatic effects in many human tumor cells. In rat bladder carcinoma cell line-804G cells, DFMO inhibited the growth of 804G cells stimulated by Fraction I or by 10% FCS [2].In female SENCAR mice with skin tumorigenesis model, both oral intake of DFMO (1.5-2.0% wt/vol) and intraperitoneal injection of DFMO (20mg,i.p. and 5mg,i.p.) reduced the sizes and numbers of skin tumor compared to control group [3].
    
    1. H. M. Wallace, A. V. Fraser and A. Hughes. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003).
    2. Homma Y, Ozono S, Numata I, Seidenfeld J,et al. Alpha-Difluoromethylornithine inhibits cell growth stimulated by a tumor-promoting rat urinary fraction. Carcinogenesis. 1985 Jan;6(1):159-61.
    3. Weeks CE, Herrmann AL, Nelson FR, Slaga TJ. Alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin. Proc Natl Acad Sci U S A. 1982 Oct; 79(19):6028-32.
- Properties
  - Alternative Name
    
    DFMO,Eflornithine; 2-(difluoromethyl)-ornithine, monohydrochloride, monohydrate
    
    CAS Number
    
    96020-91-6
    
    Molecular Formula
    
    C6H12F2N2O2·HCl [H2O]
    
    Molecular Weight
    
    236.6
    
    Purity
    
    98.00%
    
    Solubility
    
    insoluble in DMSO; insoluble in EtOH; ≥11.55 mg/mL in H2O
    
    Storage
    
    Store at -20°C
    
    * For Research Use Only