Name: Dihydroergotamine mesylate
Price: 194.00 USD

- Overview
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    Background
    
    Dihydroergotamine mesylate is a partial agonist for both dopaminergic and α-adrenergic receptors. Dihydroergotamine mesylate also acts as a full agonist for the 5-HT receptor, with IC50 values being 2 nM and 2.2 nM for human 5-HT1B and 5-HT1D receptors stably expressed in HEK 293 cells and C6 glioma cells, respectively. Like other potent 5-HT receptor agonists such as sumatriptan, dihydroergotamine mesylate has been approved for acute migraine therapy.
    
    1. Lesage AS, Wouters R, Van Gompel P, et al. Agonistic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines. British Journal of Pharmacology, 1998, 123(8): 1655-1665.
    2. Schaerlinger B, Hickel P, Etienne N, et al. Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. British Journal of Pharmacology, 2003, 140(2): 277-284.
    3. Villalón CM, Bom AH, Den Boer MO, et al. Effects of S9977 and dihydroergotamine in an animal experimental model for migraine. Pharmacological Research, 1992, 25(2): 125-137.
- Properties
  - Categories
    
    An ergot derivative with agonistic activity for α-adrenergic, dopaminergic, and serotonergic receptors
    
    Alternative Name
    
    (6aR,9R,10aR,Z)-N-((2R,5S,10aS,10bS)-5-benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-2H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carbimidic acid compound with methanesulfonic acid (1:1)
    
    CAS Number
    
    6190-39-2
    
    Molecular Formula
    
    C34H41N5O8S
    
    Molecular Weight
    
    679.78
    
    Appearance
    
    White solid
    
    Solubility
    
    insoluble in EtOH; ≥102.2 mg/mL in DMSO; ≥2.85 mg/mL in H2O with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    C[[email protected]@](/N=C(O)/[[email protected]](C1)([H])C[[email protected]]2([H])C3=C4C(C[[email protected]@]2([H])N1C)=CNC4=CC=C3)(O5)C(N([[email protected]]5(O)[[email protected]]6([H])CCCN67)[[email protected]@](C7=O)([H])CC8=CC=CC=C8)=O.CS(O)(=O)=O
    
    * For Research Use Only

Dihydroergotamine mesylate

Dihydroergotamine mesylate

Background

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