Name: Dibutyryl-cAMP, sodium salt
Price: 209.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    Dibutyryl-cAMP sodium salt is a cell-permeable cAMP that activates cAMP-dependent protein kinase (PKA) and is a phosphodiesterase inhibitor. Because it mimics cAMP and induces normal physiological responses when added to cells under experimental conditions, dibutyryl-cAMP is widely used in a variety of research applications[1,2].
    
    [1]. Bartsch M, Zorn-Kruppa M, Kühl N, et al. Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells. Biological Chemistry, 2003, 384(9): 1321-1326.
    [2]. Rundfeldt C, Steckel H, Sörensen T, et al. The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Archives of Dermatological Research, 2012, 304(4): 313-317.
- Properties
  - Categories
    
    Cell-permeable cAMP analog that activates cAMP-dependent protein kinases
    
    Alternative Name
    
    sodium (4aR,6S,7R,7aR)-6-(6-butyramido-9H-purin-9-yl)-7-(butyryloxy)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-2-olate 2-oxide
    
    CAS Number
    
    16980-89-5
    
    Molecular Formula
    
    C18H23N5NaO8P
    
    Molecular Weight
    
    491.37
    
    Appearance
    
    A solid
    
    Purity
    
    98.00%
    
    Solubility
    
    ≥49.1 mg/mL in H2O; ≥23.7 mg/mL in DMSO; ≥3.21 mg/mL in EtOH with gentle warming and ultrasonic
    
    Storage
    
    Store at -20°C
    
    SMILES
    
    CCCC(NC1=NC=NC2=C1N=CN2[[email protected]]3O[[email protected]]4[[email protected]@H](OP(OC4)([O-])=O)[[email protected]]3OC(CCC)=O)=O.[Na+]
    
    * For Research Use Only