Name: DHX58 Polyclonal Antibody (1.08 mg/mL) for WB, ELISA
Price: 253.00 USD

Overview
- Calculated MW: 77 kDa
  Observed MW: Refer to figures
  Gene Accession: BC014949
  
  Please contact us at for specific academic pricing.
  
  Background
  
  Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.
Properties
- Host
  
  rabbit
  
  Antibody Type
  
  polyclonal
  
  Isotype
  
  IgG
  
  Reactivity
  
  human; rat
  
  Immunogen
  
  Fusion protein of human DHX58
  
  Purification
  
  Antigen affinity purification
  
  Conjugate
  
  Unconjugated
  
  Formulation
  
  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
  
  Storage
  
  Store at -20°C. Avoid freeze-thaw cycles.
  
  Concentration
  
  1.08 mg/mL
  
  Antigen
  
  D11LGP2, D11lgp2e, DEXH (Asp Glu X His) box polypeptide 58, DEXH box polypeptide 58, DHX 58, DHX58, DHX58, LGP 2, LGP2, Ortholog of mouse D11lgp2, Probable ATP dependent helicase LGP2, Probable ATP dependent RNA helicase DHX58, Probable ATP-dependent helicase LGP2, Probable ATP-dependent RNA helicase DHX58, Protein D11Lgp2 homolog, RIG-I-like receptor LGP2, RLR, RNA helicase LGP2 (UniProt:Q96C10)
  
  * For reference only.

Applications

Application

WB; ELISA

Application	Dilutions
WB	1:1000-1:5000
ELISA	1:5000-1:10000

DHX58 Polyclonal Antibody (1.08 mg/mL) for WB, ELISA

DHX58 Polyclonal Antibody (1.08 mg/mL) for WB, ELISA

Background

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