Daptomycin ReadyMade™ Solution

Daptomycin ReadyMade™ Solution

Catalog Number:
Mfr. No.:
TOK-D108-10x0.5 ML
  • Size:
    10x0.5 mL
    Add to Cart:
      • Overview
        • Daptomycin ReadyMade™ Solution is provided as a sterile-filtered solution formulated in ~ 10% β-cyclodextrin saline solution at a concentation of 1 mg/ml.
          Daptomycin is a unique 13-residue cyclic anionic lipopeptide antibiotic derived from Streptomyces roseosporus that is effective against Gram-positive bacteria. This holoenzyme is composed of three subunits, encoded by the dptA, dptBC, and dptD genes, each responsible for incorporating particular amino acids into the peptide. The cloned dpt gene cluster allows study of Daptomycin biosynthesis and discovery of novel lipopetides through pathway engineering.
          Resarch has shown that Daptomycin requires calcium to form a micellar structure in solution and to bind to bacterial model membranes.

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          Daptomycin peptides interact with anionic phospholipids in the membrane of Gram-positive bacteria. Peptides integrate into the membrane by a calcium-mediated process and interact with membrane phospholipid head groups and acyl chains. Finally, a pore or channel is formed which can kill the cell by membrane disruption/depolarization or cellular uptake of Daptomycin leading to disruption of intracellular processes such as synthesis of DNA, RNA, and protein which results in bacterial cell death. The activity of Daptomycin is dependent on the presence of physiologic levels of free calcium ions. Researchers found a gradual dissipation of membrane potential, thus membrane depolarization is an inherent part of its mechanism of action (Silverman et al, 2003).

      • Properties
        • CAS Number
          Molecular Formula
          Molecular Weight
          Other Properties
          Source: Streptomyces roseosporus

          * For research use only

      • Applications
        • Application Description
          Spectrum: Daptomycin targets Gram-positive organisms including GRE (glycopeptide-resistant Enterococci) and MRSA (methicillin-resistant Staphylococcus aureus).

          Microbiology Applications: Daptomycin has been used to study the impact of Staphylococcal accessory regulator (sarA) on Daptomycin susceptibility of Staphylococcus aureus. The mutation of sarA did not affect the Daptomycin MIC but resulted in increased susceptibility in vivo in the context of an established biofilm (Weiss et al, 2009).
          Representative MIC ranges for Daptomycin from our Antimicrobial Index appear below.
          Vancomycin-resistant Enterococcus faecalis - ≤0.015 μg/mL - 4 μg/mL
          MRSA: 0.25 μg/mL - 2 μg/mL



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