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Overview
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Background
D-AP5 is a selective NMDA receptor antagonist (Kd = 1.4 μM), which can inhibit the glutamate binding site of NMDA receptors competitively[1]. D-AP5 causes sensorimotor disorders during spatial task, but gradually worsens as animals fail to learn. Rats treated with D-AP5 show a space-dependent delay-dependent defect in the delay-matched placement protocol of the water maze[2].
[1]. Evans R H, Francis A A, Jones A W, et al. The effects of a series of ω-phosphonic α-carboxylic amino acids on electrically evoked and excitant amino acid-induced responses in isolated spinal cord preparations. Br. J. Pharmacol, 1982, 75(1): 65-75.
[2]. Morris R G, et al. N-methyl-d-aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d-AP5 interacts directly with the neural mechanisms of spatial learning. Eur J Neurosci, 2013, 37(5): 700-17.
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