Cytosporone B

- Overview
  - Cytosporone B (Dothiorelone G; Csn-B) is a naturally occurring octaketide isolated from an endophytic fungus Cytospora sp, acting as an agonist for the nuclear orphan receptor Nur77 (EC50 = 0.278 nM) with antitumor activity. Nuclear orphan receptor Nur77 has important roles in many biological processes. Csn-B binds specifically to the ligand-binding domain of Nur77 with high affinity (IC50=0.278 nM) and stimulates Nur77-dependent transactivational activity towards target genes including Nr4a1 (Nur77) itself, which contains multiple consensus response elements allowing positive autoregulation in a Csn-B-dependent manner. Csn-B also elevates blood glucose levels in fasting C57 mice, an effect that is accompanied by induction of multiple genes involved in gluconeogenesis.
    
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- Properties
  - Categories
    
    Disease Research Fields
    
    CAS Number
    
    321661-62-5
    
    Molecular Formula
    
    C18H26O5
    
    Molecular Weight
    
    322.4
    
    Purity
    
    ≥98%
    
    Storage
    
    Powder: store in -20°C freezer for up to three years, store in 4°C freezer for up to two years
    In solvent: store in -80°C freezer for up to six months, store in -20°C freezer for up to two months
    
    Shipping
    
    Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
    
    SMILES
    
    O=C(OCC)CC1=CC(O)=CC(O)=C1C(CCCCCCC)=O
    
    * For research use only

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