Cynomolgus PBMCs

Cynomolgus monkey peripheral blood mononuclear cells (PBMCs) are immune response cells that include lymphocytes, monocytes and dendritic cells from monkeys. Monkey PBMCs are widely used in clinical research because they provide a convenient, minimally invasive way to study the immune system and its response to diseases, infections and therapies. Cynomolgus PBMCs are useful in understanding various physiological and pathological mechanisms in monkeys. Lab4Paws collaborates with a network of veterinary clinics to source animal biospecimens complete with patient metadata, indication and treatment.

Key Highlights of Cynomolgus PBMCs
• Protection from Lethal Challenge
All vaccinated macaques were fully protected from a high-dose ZEBOV challenge, showing no clinical signs of disease, while control animals succumbed to infection.
• Immune Response
The vaccine elicited strong GP-specific humoral and cellular immune responses across all routes of administration. Long-term memory B and T cell responses were observed, indicative of robust immunity post-vaccination.
• Comparison of Delivery Routes
Intranasal and oral routes, though less common in vaccine delivery, were as effective as intramuscular administration, offering alternative strategies for mass vaccination in outbreak scenarios.
• Safety
The vaccine showed no adverse effects across all tested macaques, underscoring its potential for human application. This research highlights the potential of mucosal and systemic vaccination strategies for Ebola virus, providing insights into immune mechanisms and paving the way for improved vaccine accessibility during outbreaks.

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