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Overview
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CD61 (GPIIIa) is a 90-110 kDa transmembrane glycoprotein (integrin family) expressed on platelets, megacaryocytes, osteoclasts, endothelial cells and other cell types, including leukocytes and smooth muscle cells. CD61 associates with CD41 or CD51 molecules to form heterodimeric adhesion receptors. CD41/CD61 complex is one of the earliest markers of the megakaryocytic lineage. It binds to fibronectin, fibrinogen and von Willebrand factor, and is involved in platelet aggregation. CD51/CD61 complex is involved in modulating migration and survival of angiogenic endothelial cells.
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