Name: CyFlow™ CD161 FITC
Price: 456.00 USD

- Overview
  - Please contact us at for specific academic pricing.
    
    Background
    
    CD161 (Nkrp1; natural killer receptor protein 1 or Klrb1; killer cell lectin-like receptor subfamily b member 1) is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.
- Properties
  - Host
    
    mouse
    
    Antibody Type
    
    monoclonal
    
    Isotype
    
    IgG1
    
    Reactivity
    
    rat
    
    Clone
    
    10/78
    
    Immunogen
    
    Splenic cells purified from the LEW rat
    
    Conjugate
    
    FITC
    
    Formulation
    
    The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide.
    
    Storage
    
    Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze.
    
    Concentration
    
    0.5 mg/mL
    
    Regulatory Status
    
    RUO
    
    Antigen
    
    NKR, NKR-P1A , NKRP1A
    
    * Research use only
- Applications
  - Application
    
    Flow Cytometry
    
    Application Description
    
    The reagent is designed for Flow Cytometry analysis. Working concentrations should be determined by the investigator.
    
    Emission Maximum: 518 nm
    Excitation Maximum: 490 to 495 nm